Beilstein J. Org. Chem.2018,14, 318–324, doi:10.3762/bjoc.14.20
confirm the viability of preparing the desired pyrimidinones in short reaction times. Yields typically higher than those published earlier using conventional batch or microwave processes were achieved.
Keywords: continuous-flow; desulfurisation; norbornene-fusedheterocycles; pyrimidinones; retro-Diels
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Graphical Abstract
Scheme 1:
Flow synthesis for the preparation of fused pyrimidinones 9–14 by rDA reaction. Solvent and conditi...